Mitofusion Underlines the Ability of Mitochondrial Peptide MOTS-c to Prompt GLUT4 Translocation
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چکیده
منابع مشابه
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA. Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-a...
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Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian popul...
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15 صفحه اولTUG cleavage regulates GLUT4 translocation Endoproteolytic cleavage of TUG regulates GLUT4 glucose transporter translocation*
Jonathan S. Bogan, Bradley R. Rubin, Chenfei Yu, Michael G. Löffler, Charisse M. Orme, Jonathan P. Belman, Leah J. McNally, Mingming Hao, and James A. Cresswell From the Section of Endocrinology and Metabolism, Department of Internal Medicine, and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8020 Running head: TUG cleavage regulates GLUT4 translocation Add...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2020
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2020.10.172